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KMID : 1098420070150060398
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 6 p.398 ~ p.404
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Comparison of Immuno-Modulatory Regulatory Activities of Rubus coreanus Miquel by Ultra High Pressure Extracts Process
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Kwon Min-Cheol
Lee Hyeon-Yong
Kim Cheol-Hee
Na Chun-Su
Kim Jin-Chul
Kwak Hyeong-Geun
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Abstract
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This study was performed to investigate the enhancement of anticancer activities and immuno modulatary activities from R. coreanus. by ultra high pressure extracts process. The cytotoxicity on human kidney cell (HEK293) was showed below 19.5% in adding 1.0 concentration. The anticancer activity was increased over 10% by high pressure processing in AGS and A549 cells. The immune cell growth using human immune B and T cells was improved by the high pressure extracts of Rubus coreanus in adding 1.0 concentration. The secretion of two kinds of cytokine, the IL-6 and from human immune B and T cells were also enhanced in adding extracts by high pressure process of R. coreanus. The ultra high pressure extraction technique showed high efficiency in extracting of bioactive compound. The ultra high pressure technique could be used combined with other technique to improve the extracting rate and extracting efficiency.
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KEYWORD
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Rubus coreanus Miquel, Ultra high pressure, anticancer activities, immune activities, cytokine, NK cell
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